Pancreatic beta-cell dysfunction results in reductions of insulin synthesis/secretion, cell survival, and insulin sensitivity thereby inducing diabetes mellitus. selleck kinase inhibitor In this study, how nanomolar melatonin regulates insulin synthesis and secretion in rat insulinoma INS-1E cells was investigated. At melatonin concentrations of…[Read more]

Accordingly, such marking boosts low-salience meanings (“glittery”, here the literal meaning) which are less-frequent, less-familiar, less-prototypical, and less-conventionalized (The Graded Salience Hypothesis, see Giora, Cognitive Linguistics, 1997, 8, 183; Giora, On our mind Salience, context and figurative language, Oxford University Press,…[Read more]