In diet-induced obese mice, EPO is protective for white adipose tissue inflammation and gives rise to a gender specific response in weight control associated with white fat mass accumulation. Erythropoietin regulation of fat mass is masked in female mice due to estrogen production. EPOR is also expressed in bone marrow stromal cells (BMSC) and EPO…[Read more]

As compared to the published data on PK of pdFIX, Kedrion FIX displayed a longer half-life (22.37-55.73hrs), reduced clearance, and regular volume of distribution at PK I by both NCA and OCM. SBI-0206965 cell line The comparison of outcomes of PK II with those of PK I by OCM, also showed significant changes, particularly in patients on…[Read more]