Chronic inflammation induces Barrett Esophagus (BE) which can advance to esophageal adenocarcinoma (EAC). Elevated levels of IL-1b, IL-6, and IL-8 together with activated NF-kB, have been identified as important mediators of tumorigenesis. The inflammatory milieu apart from cancer cells and infiltrating immune cells, contains myofibroblasts (MF)…[Read more]

Talaromyces marneffei is a dimorphic fungus that has emerged as an opportunistic pathogen particularly in individuals with HIV/AIDS. Since its dimorphism has been associated with its virulence, the transition from mold to yeast-like cells might be important for fungal pathogenesis, including its survival inside of phagocytic host cells. We…[Read more]