Because clozapine and risperidone have been shown to reduce neuroinflammation in humans and mice, the Clozapine and Risperidone in Progressive Multiple Sclerosis (CRISP) trial was conducted to determine whether clozapine and risperidone are suitable for progressive multiple sclerosis (pMS).

The CRISP trial (ACTRN12616000178448) was a…[Read more]

4 to 33.8%, NSE values that ranged from 0.33 to 0.92, and R2 values that ranged from 0.86 to 0.97. Results showed that 2D rain-on-grid HEC-RAS simulations can produce realistic simulations of stage hydrograph response when (1) areal effective precipitation is used for 2D HEC-RAS rain-on-grid forcing’s, (2) HEC-RAS is calibrated to observed data…[Read more]