Taken together, our study demonstrates that Kaempferol is a potent inhibitor of Nrf2 and can be used as a natural sensitizer and anti-cancer agent for lung cancer therapeutics.Substantial variation in relaxation rate exists among cardiomyocytes within small volumes of myocardium; however, it is unknown how this variability affects the overall…[Read more]

In conclusion, reduced activity of SPPL2a protease in monocytes from AS predisposes to endosomal accumulation of CD74 and CD74 N-terminal fragments, which, upon IFNγ-exposure, is deposited at the plasma membrane and can be recognized by anti-CD74/CLIP autoantibodies. This article is protected by copyright. All rights reserved. This article is…[Read more]

In conclusion, reduced activity of SPPL2a protease in monocytes from AS predisposes to endosomal accumulation of CD74 and CD74 N-terminal fragments, which, upon IFNγ-exposure, is deposited at the plasma membrane and can be recognized by anti-CD74/CLIP autoantibodies. This article is protected by copyright. All rights reserved. This article is…[Read more]

In conclusion, reduced activity of SPPL2a protease in monocytes from AS predisposes to endosomal accumulation of CD74 and CD74 N-terminal fragments, which, upon IFNγ-exposure, is deposited at the plasma membrane and can be recognized by anti-CD74/CLIP autoantibodies. This article is protected by copyright. All rights reserved. This article is…[Read more]

In conclusion, reduced activity of SPPL2a protease in monocytes from AS predisposes to endosomal accumulation of CD74 and CD74 N-terminal fragments, which, upon IFNγ-exposure, is deposited at the plasma membrane and can be recognized by anti-CD74/CLIP autoantibodies. This article is protected by copyright. All rights reserved. This article is…[Read more]