Water resources in Central Asia are very scarce due to natural and anthropogenic impacts. Water shortages have been a major factor hampering the socio-economic development of Central Asia. Exploring internal interactions among climate change, human activities and terrestrial hydrological cycles will help to improve the management of water…[Read more]

The NAFLD-updated PBPK model accurately predicts in vivo metabolism of perc through oxidative and conjugative pathways in all tissues across disease states and strains, but underestimated parent compound concentrations in blood and liver of NAFLD mice. Conclusions We demonstrate the application of PBPK modeling to predict the effects of…[Read more]