Deficit irrigation (DI) has been emerging as an important technique for enhancing crop water productivity (WP). However, advantage of DI under varying nitrogen (N) application rates remains unclear. Field experiments were conducted during 2012-2014 to investigate the impacts of six irrigation levels[FI (full irrigation), DI10, DI20, DI30, DI40 and…[Read more]

A series of novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazinonaphthyridines were identified as potent and selective agonists of the 5-HT2C receptor. Optimizations performed on a previously reported series of racemic tetrahydroquinoline-based tricyclic amines, delivered an advanced drug lead,…[Read more]

A series of novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazinonaphthyridines were identified as potent and selective agonists of the 5-HT2C receptor. Optimizations performed on a previously reported series of racemic tetrahydroquinoline-based tricyclic amines, delivered an advanced drug lead,…[Read more]

A series of novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazinonaphthyridines were identified as potent and selective agonists of the 5-HT2C receptor. Optimizations performed on a previously reported series of racemic tetrahydroquinoline-based tricyclic amines, delivered an advanced drug lead,…[Read more]